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compulsion - A strong, irresistible urge to do something, often against one's better judgement.

His gambling problem stemmed from a deep psychological compulsion.

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bonkers - Mentally unbalanced, mad and crazy, usually meant humorously

There were many long stretches of time that Joan was cooped up in the house with her kids, and it was making her go bonkers.

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loony - Crazy or silly

The patients in the mental hospital could be described as loony, but the doctors tried to treat them as normal human beings with normal problems in order to try to help them get better.

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hysterical - Having uncontrolled extreme emotion

When Amy found out that her house had been destroyed by the tornado, she broke down into hysterical crying, and could not be comforted for hours.

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lunatic - A person who is crazy

Martha was a defensive driver, to be safer with regards to a possible lunatic behind the wheel of another car.

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loudmouth - Someone who speaks loudly and without thinking, often causing trouble or embarrassment.

Even though he was a real loudmouth, always bragging about his achievements and rarely listening to others, he was still amazingly successful.

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crank - Someone who others think has unusual ideas or behaves strangely

Bill was seen as crank by his friends, because of the way he always spoke of the dangers of eating meat and being vaccinated.

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berserk - To behave in a wild and uncontrolled way as a result of something unexpected happening.

When Anne found out that she had lost all her money as a result of stock fraud, she went berserk, running around the house, screaming and breaking dishes.

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deranged - Behaving in an uncontrolled or dangerous way because of mental illness

Charles Manson led a group of followers who became mentally deranged as a result of taking too many psychedelic drugs

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mischievous - Playfully causing trouble or annoyance, often in a fun or harmless way.

Her mischievous cat knocked over the plant just to get her attention.

adjective

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mercurial - Changing emotions suddenly and often

Fred loved almost everything about his wife except her mercurial behavior, where her moods changed suddenly between sadness and happiness, or love and anger

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crackpot - A slightly strange or foolish person

Wearing mismatched clothing and yelling to nobody in particular, the crackpot was amusing and ignored by the people who passed him by.