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throes - Intense or violent pain and struggle, especially accompanying birth, death, or great change

Samantha experienced agonizing pain during the throes of childbirth.

adjective

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grueling - Extremely tiring and demanding

Troops go through grueling training before they can finally serve their country.

adjective

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strenuous - Requiring great effort, energy, or strength, needing vigorous or intense in activity or action.

Hiking up the mountain was a strenuous task, but the view was worth it.

noun

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ordeal - A painful or horrific experience, especially a protracted one

Knowing it was a fight to the death, the gladiator realized that this was an ordeal he would have to overcome if he wanted to survive.

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afflicted - Suffering from a serious problem, illness, or pain, be it mental or physical.

Many people are afflicted with anxiety in high-pressure situations.