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deranged - Behaving in an uncontrolled or dangerous way because of mental illness

Charles Manson led a group of followers who became mentally deranged as a result of taking too many psychedelic drugs

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crank - Someone who others think has unusual ideas or behaves strangely

Bill was seen as crank by his friends, because of the way he always spoke of the dangers of eating meat and being vaccinated.

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batty - Mad and slightly crazy, usually in a humorous way

The computer system wouldn't let Greg log on or change his password, and it was driving him batty.

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maniac - Someone who is mentally ill tending towards violent and dangerous behavior.

The film’s villain was portrayed as a ruthless maniac with no regard for human life.

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loony - Crazy or silly

The patients in the mental hospital could be described as loony, but the doctors tried to treat them as normal human beings with normal problems in order to try to help them get better.

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kooky - Strange and different, in a funny way

Salvador Dali's kooky appearance was only exceeded by his even more bizarre paintings.

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berserk - To behave in a wild and uncontrolled way as a result of something unexpected happening.

When Anne found out that she had lost all her money as a result of stock fraud, she went berserk, running around the house, screaming and breaking dishes.

adjective

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nuts - Crazy, insane, or stupid, often in a humorous way

Bill's friends thought he was nuts for swimming in the middle of the winter.

adjective

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hysterical - Having uncontrolled extreme emotion

When Amy found out that her house had been destroyed by the tornado, she broke down into hysterical crying, and could not be comforted for hours.

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blabbermouth - An overly talkative person who speaks without thinking.

Don't tell Jerry things you don't want others to know about, because you can’t trust a blabbermouth with secrets.

adjective

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bonkers - Mentally unbalanced, mad and crazy, usually meant humorously

There were many long stretches of time that Joan was cooped up in the house with her kids, and it was making her go bonkers.

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lunatic - A person who is crazy

Martha was a defensive driver, to be safer with regards to a possible lunatic behind the wheel of another car.