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pang - A sudden sharp pain or painful emotion

The year was 1900, and Dmitri felt a pang of nostalgia and regret as he boarded the boat for America, knowing that he would probably never see his 'old world' again.

adjective

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afflicted - Suffering from a serious problem, illness, or pain, be it mental or physical.

Many people are afflicted with anxiety in high-pressure situations.

adjective

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excruciating - Intensely painful

Becky had to see the dentist because her toothache was causing her excruciating pain.

adjective

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strenuous - Requiring great effort, energy, or strength, needing vigorous or intense in activity or action.

Hiking up the mountain was a strenuous task, but the view was worth it.

adjective

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agonizing - Something that causes great physical or mental pain.

After she took the final exam, it was agonizing to her that for a whole week she wouldn't find out the results.

noun

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angst - A feeling of deep anxiety or dread, typically an unfocused one about the human condition or the state of the world in general

Edvard Munch's famous painting, "The Scream," is often viewed as an expression of angst in an uncertain world.

adjective

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grueling - Extremely tiring and demanding

Troops go through grueling training before they can finally serve their country.

noun

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shackles - A device, such as a chain or cuff, designed to physically limit or control a person or thing's movement.

Shackles were placed on the prisoner's feet so that he would not be able to run away and escape.

verb

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bruise - To hurt someone emotionally or physically, leaving a lasting feeling of pain or vulnerability.

The teacher's harsh words bruised his self-esteem.

noun

See verb

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burden - something you carry or withstand with much difficulty.

Financial debt can be a huge burden on families.

noun

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standstill - A halt in activity, usually temporary but total.

Traffic came to a standstill after the accident on the highway.

noun

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cramps - A painful, involuntary contraction of muscles

When Sharon got cramps in her stomach after eating the fish, she suspected that it may have been spoiled.