noun
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anguish - Severe mental or physical pain or suffering
See verb
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torment - Severe physical or mental suffering
adjective
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afflicted - Suffering from a serious problem, illness, or pain, be it mental or physical.
verb
See noun
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torment - Cause to experience severe mental or physical suffering
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shackles - A device, such as a chain or cuff, designed to physically limit or control a person or thing's movement.